For flights, we're plugged into exactly the same systems (called GDS's or Global Distribution Systems, https://en.wikipedia.org/wiki/Global_Distribution_System) that Expedia, Orbitz, etc use for flights. For hotels, we're using the Expedia Affiliate Network right now.
It's actually a fairly complicated business development process - we make money the same way the other travel booking/OTA (online travel agency) sites like Expedia/Orbitz do, but we think our differentiation is the simplicity of the site and social features we've built. If people have a good experience and share the site with their friends, then we will grow organically without a lot of expensive advertising.