I agree, do some exercises and stretches and you'll be fine. Also map some of functions you use often to better places. I myself think M-x is an annoying combination so I made it to C-x C-m and find it much more comfortable.

Also to the guy who asked why not use Vim or another editor because it's more comfortable? Come on, it the same reasons all over again. Extensibility is probably the biggest reason. I also can't stand Vim Script (or trying to use Python/Ruby/whatever to script Vim.) And in some cases the Emacs community writes the kind of stuff I like more, modes with really good syntax highlighting and indentation and such.

I find Vim's indentation especially lacking compared to Emacs.