Survey took 15 years, and 19,831 participants. Median follow-up was 8.1 years. Further research is required.
Methods
Adult participants who reported usual intake from two valid 24-h dietary recalls were included from the National Health and Nutrition Examination Survey in 2003–2018 (n = 19,831). Mortality status as of December 2019 was obtained through linkage to the National Death Index. Average eating duration was categorized as <8, 8–<10, 10–<12, 12–14 h (mean duration), >14–16, and >16 h. Multivariable-adjusted hazard ratios (HRs) were derived.
Results
During a median follow-up of 8.1 years, compared with eating duration of 12–14 h, eating duration <8 h was robustly associated with higher cardiovascular mortality (HR, 2.35 [95 % CI, 1.39–3.98]), but not with all-cause and cancer mortality. The positive association with cardiovascular mortality remained consistent across 8 subgroups stratified by race/ethnicity, socioeconomic factors, and smoking status, and survived 14 sensitivity analyses. However, the association with all-cause mortality did not survive many sensitivity analyses.
Conclusions
Although a positive association was observed between eating duration <8 h and cardiovascular mortality, further research is required to understand whether this risk is attributed to the short eating duration itself or residual confounding resulting from its contributing factors.
15 years ago, was intermittent fasting even a thing back then? I wonder how many of the people eating within an 8 hour window didn't do it because of a diet, but instead because of an eating disorder or some other disease.
This is another reminder that, in the short term, a lot of research about health amounts to very little signal because the confounding factors are so varied.
We can, of course, learn a lot about health very quickly, but much of the reporting is sensationalised nonsense.
Survey took 15 years, and 19,831 participants. Median follow-up was 8.1 years. Further research is required.
Methods
Adult participants who reported usual intake from two valid 24-h dietary recalls were included from the National Health and Nutrition Examination Survey in 2003–2018 (n = 19,831). Mortality status as of December 2019 was obtained through linkage to the National Death Index. Average eating duration was categorized as <8, 8–<10, 10–<12, 12–14 h (mean duration), >14–16, and >16 h. Multivariable-adjusted hazard ratios (HRs) were derived.
Results
During a median follow-up of 8.1 years, compared with eating duration of 12–14 h, eating duration <8 h was robustly associated with higher cardiovascular mortality (HR, 2.35 [95 % CI, 1.39–3.98]), but not with all-cause and cancer mortality. The positive association with cardiovascular mortality remained consistent across 8 subgroups stratified by race/ethnicity, socioeconomic factors, and smoking status, and survived 14 sensitivity analyses. However, the association with all-cause mortality did not survive many sensitivity analyses.
Conclusions
Although a positive association was observed between eating duration <8 h and cardiovascular mortality, further research is required to understand whether this risk is attributed to the short eating duration itself or residual confounding resulting from its contributing factors.