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I don't have a published study to back this up, but in my 10 < n < 100 experience, the alcohol suppression effect is limited to occasional-to-moderate drinkers.

Giving a GLP-1 to a heavy drinker/alcoholic results in a skinny alcoholic.

Given that the overwhelming majority of alcohol is consumed by heavy+ drinkers this isn't the gamechanger people think it is.



I'm a heavy drinker (1.5 bottles of wine a day -or the equivalent- everyday, for at least 5 years). I started a GLP-1 at 2.5mg two weeks ago after the most recent study was released[1].

In just the two weeks at that low dose it's been quite effective.

In fact the only reason I'm replying to your comment is because instead of being a bottle deep in front of the TV at this point in the evening I got bored after one glass and decided to noddle around on the internets.

Ask any heavy drinker/alcoholic and they will tell you that one doesn't just have 'one' drink and then move on with something else. One is always too much, and never enough. Now it feels like enough.

Happy the share more if you like :)

1. https://jamanetwork.com/journals/jamapsychiatry/fullarticle/...


N = 14 053 for https://jamanetwork.com/journals/jamanetworkopen/fullarticle... , which looked at if GLP-1 RA use was associated with lower incidence and recurrence of alcohol use disorder.




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