I find the big advantage of the reduced layout is that it moves the mouse/trackpad closer, reducing strain on my arm as a reach between the two.

I like the magic keyboard because it requires little effort to actuate the key and makes it easy to switch up my working position as it is so similar to the laptop keyboard.

I wish Apple would offer a combined keyboard and trackpad for desktop use that was the same as their laptops. I find being able to switch hands on the trackpad reduces strain.