the genetics of obesity are amazing.
we all have a unique combination of genes, and epigenic features that influece the endocrine and neuronal pathways that drive the desire to eat, these different genotypes affect our behaviour. Ozempic is putting a thumb on the scales of this pathway, but this pathway is balanced differently in all of us.
Think of the most hungry you have ever been, in some people this never stops, in others it's dialed up or down.
there are some great papers on fat labradors that hint at how these different genotypes are linked to our desire to eat and how that shifts our behaiour.
Guide dogs are highly selected for trainability, and positive reinforcement with food reward plays an important role in their training.
I think it was Yeo, found 22% of pet Labradors and 80% of Labrador guide dogs sampled carried a 14 BP deletion in the POMC gene, which forms part of this pathway.
there are some great papers on fat labradors that hint at how these different genotypes are linked to our desire to eat and how that shifts our behaiour. Guide dogs are highly selected for trainability, and positive reinforcement with food reward plays an important role in their training. I think it was Yeo, found 22% of pet Labradors and 80% of Labrador guide dogs sampled carried a 14 BP deletion in the POMC gene, which forms part of this pathway.
https://doi.org/10.1007/s00125-016-4187-x https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873617/