Just as an FYI for the interested, there is a self-hosted version of clojurescript now, it enables macros in the same runtime with some caveats but the main downside (AFAIK) is increased bundle size, which is less relevant for node.js.
There was a self-hosted CLJS project for Node.js which is now abandoned. It was called lumo. It came with a custom image of Node.js with lumo built-in for better startup times since the JS bundle of self-hosted CLJS is quite large resulting in not so great startup out of the box. Nbb is just a library that you can use with any Node.js version. That said, it might be worth revisiting the self-hosted CLJS approach at some point.
