asan/ubsan do not detect uninitialized memory reads (though ubsan can detect when bools take on invalid bit patterns from uninitialized memory), and msan requires rebuilding the standard library or something, so I've never used msan. Valgrind is slow, but detects uninitialized memory reads properly, and doesn't require rebuilding the app (which is useful when running a complex or prebuilt app for short periods of time).

On the topic of profiling, callgrind can count exact function calls and generate accurate call graphs, which I find useful for not only profiling, but tracing the execution of unfamiliary code. I just wish rr had similarly fast tooling (pernosco is close enough to be useful, but I think there's value in exploring different workflows than what they picked).