Xfce relies on GTK, so it would seem subject to the whims of the Gnome team in a lot of ways. Do you know of any plans to wrest control of GTK away or fork it?
That's not the problem. The problem is that any Flatpak I download also comes with several gigabytes of GNOME runtime dependencies, which is absurd and shouldn't be treated as "the new normal" of software distribution. Running to alternative DEs doesn't solve the problem.
That was already the normal long before flatpak. Installing the same packages with your distro package manager will also install the same several gigabytes. The number you see in flatpak might be an illusion though, the real amount of space taken up on disk is less: https://blogs.gnome.org/wjjt/2021/11/24/on-flatpak-disk-usag...
So flatpak may actually be a solution to the problem that you don't realize. It can only cause a big issue if you have a lot of old software that never updates the runtime.
There is fvwm, vtwm even lxde, you know.