I've found setting my mouse sensitivity (pointer speed) to maximum helps reduce wrist movement. It takes just a little getting use to, but once you adjust to the increased speed your wrist moves very little. This is especially good for large displays (I have a triple monitor setup).
Switch to a touchpad keyboard. Try an adesso tru-form. It will feel really weird and uncomfortable for the first week, and then you won't look back. The only thing I can't do effectively on it now is PC games, especially FPSs.
