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It depends on how you want to live.

For one healthcare is usually not an issue because you have a good health plan with an out of pocket maximum. Your employer pays the premiums. Out of pocket you’re looking at about $10k/yr on the higher end, barring big medical problems or issues with your insurer (sadly, always a possibility). Let’s call that $1k/month.

Rent also depends a lot on how many bedrooms you need and how fancy you want to go. Let’s say it’s $2.5k/month (including utilities).

At $300k/yr in California you’re taking home about $180k/yr. So that’s about $15k/month after tax and $11.5k/month after rent and healthcare (you really aren’t likely to spend that much on healthcare. More on rent if you have kids). Not including of course things like 401k which can both lower your taxable income and get extra money from your employer



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