Very nice, I can borrow the idea to teach also my kids :)

Thank you :) These originally started as something I made for my own kids while trying to teach them Greek abroad.

I’ve now added a small updates/interest page linked from the original article because several people asked whether they’ll become available somewhere.

I guess you are right but can you please provide a source of the failed trials for this case!

Looks like there are none, which is the typical result. If you worked in a drug-discovery-adjacent field, this is an utterly normal scenario:

1. University/startup company finds a promising drug candidate that works in-vitro. They make a press-release, researchers write their theses, and move on.

2. Drug companies pick that up and run small-scale tests. These tests are negative, usually because of unexpected toxicity.

Looking at the molecule in question, it's likely what happened here. It's a covalent inhibitor, meaning that it permanently binds with the protein. It's also allosteric, meaning that it binds to the target enzyme but not at the actual active site. This is a huge red flag for toxicity, because it's likely going to bind to other proteins that can have similar configurations.

3. But the underlying idea is sound, so companies keep working on alternative approaches. They are likely looking for non-covalent compounds now, or for things like "suicide inhibitors".

4. You'll see actual trials in 10-15 years after the initial press-release. Most likely for completely different compounds, targeting the same mechanism.

There was what I thought was a breakthrough in Schizophrenia diagnosis and treatment - the University of Washington held that groups of genes acting in concert were causing the disease, and, in fact, there were multiple variants of genes producing (what had always been suspected) different diseases that were bing lumped together.

For the longest time I had been trying to figure out why nobody was taking the research seriously, why there weren't diagnostic kits available that determined which variant people were actually suffering from, and using the appropriate drug regime to manage the specific condition the patient had.

Then, last year I saw a paper being discussed (some 5 - 10 years after the initial paper), and it was building on the Washington research - it appears to me now (keeping in mind that I am a layman and an outsider) that the research /had/ been taken seriously, but it's seen as a signpost on the pathway rather than the destination.

Sorry but I didn't get the hype with this post, isnt it what most of the people doing? I want to see more posts on how you use the claude "smart" without feeding the whole codebase polluting the context window and also more best practices on cost efficient ways to use it, this workflow is clearly burning million tokens per session, for me is a No

I used to work at the Ubisoft studio in Sweden, and honestly, it’s sad to see this. That studio was full of amazing, talented people who built The Division—a game that brought in massive income for Ubisoft for years.

The problems really started when Ubisoft headquarters began interfering more and more with the studio's decisions. Because of that management pressure, a lot of the top talent just decided to leave.

Ubisoft leadership has made so many bad moves lately. They wasted huge amounts of money on NFT/crypto stuff that nobody wanted. Then they made that awful comment about how "gamers should get used to not owning their games." Even if that’s where the industry is heading, saying it out loud to your own customers is just crazy. It’s like they don't understand their own audience anymore.

Hey, ok I get it for coumarin but just out of curiosity, what can introduce heavy metals in this mix?

Some people add yellow lead salts to turmeric to increase profit margins.

Turmeric and cinnamon are both notorious for lead contamination.

In many locations it's legal to sell consumables that have disgustingly high ppm of heavy metals as long as the recommended daily dose is small so that the absolute amount of heavy metals stays below a fixed threshold. Also many companies just flagrantly violate the regulatory levels.

Getting clean turmeric extract is possible by knowing which brand to trust. Natural Factors is trustworthy, they are transparent with heavy metal testing and have third-party validation in academic studies and by consumerlab.com. But even if it's clean, you would still need to manage this risk: https://www.ncbi.nlm.nih.gov/books/NBK548561

For cinnamon, avoiding coumarin is possible by making sure it's ceylon cinnamon. But I don't know of any brand selling ceylon cinnamon that I would also trust to have low heavy metal levels. The intersection of reliable brands and ceylon cinnamon sellers is a very sparse set.

> The acute hepatotoxicity caused by turmeric appears to be due to an idiosyncratic injury, perhaps immunologically mediated.

idiosyncratic means they don't know why (because they're idios?), but it happens to some people for unknown reasons. The chances are very slim that you'll have whatever pre-condition to be affected by this.

Turmeric, but I think it's only some suppliers?

Tried windsurf and the beginning was amazing, last few days I start realizing that is getting annoyingly stupid and slow. Open reddit and realized lots of people had the same issue with a lot of wild theories about it. I stopped my subscription and I am considering trying cursor just to compare. Tldr;×trying an agent Ai coding assistant was amazing and I think I will never go back!

They use a lot of custom models and logic chaining, so I think this is more search and retrieval optimization or similar problems, I guess maybe some Anthropic API issues as well. I’ve seen the variance too and was wondering if was load related. Overall, still loving it, even if there’s some bleeding edge bumpiness.

Thank you for sharing. I can assure you that there are many people with exactly the same difficulties including me :)

You can't compete with HFT firms even if you have this equipment because you need to install your equipment in a colocation, aka a data center that exchanges sending their raw data and your equipment trades there. In this kind of trading receiving the data nanoseconds late from the other players matters.

This is only true for arb opportunities on exchanges that offer colocation (which leaves almost all crypto exchanges as fair game). But if you can't get colocation, there isn't much point in having the FPGA anyway since the network latency is going to be so much higher than any savings from FPGA vs low level programming.

yes, this would be non-colocated on AWS. wouldn't everyone have the same network latency if they had a node in the same AWS region? and wouldn't that even the playing field, making FPGAs relevant again (you can rent an FPGA there)? i guess the importance of low latency also depends on the update rate of the exchange server.

I was incredibly fortunate to meet him at CERN the day before the Higgs boson announcement. As an intern, I encountered him the evening prior; he was dining alone in the CERN cafeteria, blending in like a kindly elderly gentleman. He was exceptionally humble and courteous. I feel so lucky that I mustered the courage to speak with him and shake his hand. Rest in peace, Mr. Higgs.

These are the kind of opportunities one must take when they present themselves. Well done.