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It's not an issue, write-new-and-swap is probably the best approach for this type of application.

I want to know so that I can make plans. Including end of life plans, in all senses.

Exactly - there are things that I would change now to make sure I make thing easier for myself and - more importantly - easier for the people around me.

Those plans should be in place regardless of the results of a blood test

I think there are many people (myself included) whose plans would change dramatically upon discovery of Alzheimer's, dementia, or some other degenerative disease. I might consider moving to somewhere with more liberal assisted suicide laws for example.

No, they shouldn’t. Makes no sense to plan for living with a mental disability if you’re not close to needing it.

I am absolutely not going to plan on a care facility right now. That sounds absolutely bogus.


Notarizing any wishes against some medical procedures in case a sudden accident ruins your ability to dissent prevents doctors from being forced to keep your body alive as long as possible.

That doesn't apply to Alzheimer's disease directly though. If you don't want to live when your conscious life is limited to short flashes of awareness among a deeply terrifying melange of visions of the past and hallucinations, DNR laws don't in any way force or even allow doctors to euthanize you. You can persist in this state for many years without ever triggering a DNR check.

That is sadly true but at least you can prevent them from feeding you through a tube when you forgot how to swallow

My genetics are such I'm more likely to drop dead of a heart attack too young.

If I were likely to develop alzheimer's, I'd make more and more expensive accommodation for power of attorney and trusts to shield assets while I was competent to do so.


I was more referring to an advance directive / living will sort of thing

That is one very, very tiny aspect of EOL planning.

Yes, like walking out into the woods before it gets too bad.

Like what? You should already have a will, life insurance, etc. even without the disease. All you're doing by knowing earlier is causing psychological harms to yourself and the people you tell, adding more years of anxiety, grief, and sadness for no gain. Think about the bigger picture.

Downsizing your house? Picking your long term care location? Changing your asset balance? Recording more photos, audio, and video?

Knowing an early, painful fate allows you to approach it with dignity.


It wasn't just "permitted." The technology under discussion here was funded by the US the DOE and Intel and deliberately transferred by the US to ASML (and not, for example, a Japanese company or Samsung) as part of a soft power exercise.

It's crazy that Europeans keep citing ASML as a strong example of European innovation.


It is a strong example of European innovation though. It’s a multinational project. I wasn’t casting shade on ASML, I was just pointing out the wording of the article implies some sort of competition between ASML and the US that does not exist.

There is always a risk of things like this. For example, to make my winecap bed, I had to get a bunch of woodchips. There is no way woodchips that one will buy in bulk are not contaminated with the spores of other wood-eating fungus.

What you learn is how to positively identify the mushrooms you intend to produce/eat. It doesn't take long. I've only had alien mushrooms show up once.


"I've only had alien mushrooms show up once" gonna be my reassuring quote of the day, thanks : )

On the other hand, the morels that seemed to come with a load of wood chips were great for the year or two we had them.

I tried growing a little wine cap bed once, and it hadn't gone well. Perhaps it was the chickens pecking at it, can't say. I do still get wine caps on occasion, but they have migrated to more far-flung parts of the yard.


> the morels that seemed to come with a load of wood chips were great for the year or two we had them.

You probably already know this, but for anyone reading, there’s a species of mushrooms that looks kind of like morels that is poisonous, potentially fatally so.

https://www.foraged.com/blog/morel-mushrooms-vs-false-morels


Yeah thanks, but it doesn't hurt to mention!

Do people ever try to irradiate or fumigate or however they’d treat the woodchips?

Maybe it would cost 10 times as much as the wood chips themselves… small batch spore bakeoffs…


Adding poisons (fumigation) is definitely not a good idea. In mushroom plants the compost/humus used to grow mushrooms is often steam boiled to sterilize it, to keep the yields high and the production safe from any dangerous contamination. It is seeded with the spores of the desired species afterwards.

Pressure cooking in small batches is the diy standard, I've had good results with a standard insta-pot

you could probably autoclave it with a standard dental/tattooing autoclave (~500 USD and requires a gas stove)

Mushrooms are everywhere. There used to be a subreddit of "weird mushrooms" like growing out of people's couches or in the bathroom, etc. In all cases, this is a sign of rot due to water intrusion.

You can grow mushrooms at home, it is fun. The only risk is that the mushrooms with high spore production are not great to have in a closed residence, especially oyster mushrooms which produce very high spore loads. There are vendors who produce cultures of sporeless oyster which can be used to grow oyster mushrooms indoors.

Outdoors, at least in most temperate areas, you are limited to things like shitake on logs or winecaps. The latter are incredibly easy to grow, and very good taste wise, but they are temperamental and basically grow on their own schedule, infrequently.



How would releasing the prisoners stop the settlers and other issues?

What Israel has been doing for decades at this point is completely unacceptable. Hamas is a bunch of terrorists, but in context they are the inevitable outcome of Israel's continuous mistreatment and ongoing antagonism against all of their neighbors stretching on for fifty years.

You really have to wonder what the hell is wrong with the Israelis that they can't stop being aggressive towards literally everyone around them.


Agreed that Israel could have taken another path the last couple decades, but it's also unreasonable to omit that they are surrounded by neighbors that want to kill them. Iran and their proxies.

What is the advantage of moving sooner vs. moving later when rough spots have been smoothed over?

You keep hoping things won't get too bad, but they will. You just keep delaying the inevitable. So it's better to switch now to get the initial hurdles of such a big change over with as soon as possible. It's not easy, getting used to completely strange behaviours and new things in general. Abandoning what worked for you for years for something completely foreign. You have to force yourself to withstand the first few days or week(s), but then it becomes the new normal and you'll be fine.

Personally, I am still on W10 and and delaying the move, so i'm not holier than thou. It's tough. But I also am a programmer/power user and am on my PC 24/7, sort of, so this disruption must be timed properly for me to make the move, which is not necessarily the case for most people/average users.

Phone on the other hand, as long as it works and does not limit me, I have no need to use different ROM, it's more of a want. But i do not see me doing anything until the system stops being supported or it breaks or something else. So it depends on how you use it.


Wine is more stable as an API to target than any of the native Linux technologies.


The problem is that software people are clueless.


And if France decides to jam you until you play nice?


it's extreemly hard to jam starlink, ask russians at war. also that gpu run results can be connected somewhere in england, and requested using ipv6 e.g. you need to start moderating internet heavily etc.


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