Oof, my Bitwarden account was created a while ago and was set to only 5,000 iterations. You can see and change the number of iterations here: https://vault.bitwarden.com/#/settings/security/security-key... (or if you don't trust links for something like your password manager: log into your web vault, click on the top-right dropdown menu, then Account settings > Security > Keys).
I've updated it to 600,000 iterations and so far don't see any noticeable impact on performance, both on desktop (using the Firefox extension) and on mobile (iOS).
Nice discovery, indeed that is very suspicious, i wish Microsoft would have sorted out permissions for Windows..
This would help notice things like that earlier
I use this: https://processhacker.sourceforge.io/ gives me notifications whenever a process create/delete services, also has a nice CPU graph in the system tray, thanks to that i noticed Windows will eat your CPU/DISKs whenever you AFK, some telemetry/update thing running in the background.. even when you just idle watching a video.. inefficient telemetry software.. sweet.. what a time to be alive
Messing around the edge://flags to toggle native notification on or off, I remembered that the default notification mode has bug currently. Also ensure you grant it permission of notification in system setting. That isn't done by default.
My impression from reading The Computer Scientist’s Guide to Cell Biology is that the reason for woefully inadequate descriptions of cellular systems, rather than any fundamental deficiency on the part of biologists, is that the systems are so dang tiny and crowded, with every molecule running into every other molecule every second or so, at sizes literally below the widths of light waves, that we just don’t have the tools to physically observe what’s happening in real-time. Even the primitive equivalents of “shooting individual components” took so much clever innovation and hard work to figure out how to do that frankly it’s amazing that we know everything that we do.
During the first part of the pandemic I watched the lectures for the Introductory Biology course [1] from MIT OpenCourseWare. I cannot recommend those highly enough!
Almost every lecture brought up and highlighted something really cool and fascinating. Like how RNA sequencing over the last couple of years has gone from expensive to almost free, and what its uses are. Or time-lapse of bacteria adapting to antibiotics. Or just the first lecture showing a video of someone sticking a syringe into a cell. There were even some labs that could be done via a normal web browser.
For me this was so much more engaging than the biology I was thought in high school, where we mostly learned things from outdated books.
A couple of my go-tos are Solar Fields and Infected Mushroom. Both are electronic; former is calm/ambient focus, latter is energetic/driving focus. Both have huuuge discographies that you can just put on shuffle
Solar Fields actually did the Mirror's Edge game soundtracks too, if you've played those. Really nice mix of ambient, almost meditative sounds. Often there's a super long, repetitive, pulsing buildup to a brief higher-energy section at the end of a track
Infected Mushroom is a wild mix of heavy Israeli dance-electronica, trance, and even rock, with a dash of metal here and there
Webamp is quite amazing. I use it on my desktop environment website. I recently added playlist support (m3u/pls/asx) and integrated lazy(er) Butterchurn so it can run as the wallpaper. Winamp/Milkdrop forever!
I just played this online Qubit game that I thought I would put down after a few minutes. Ended up playing for 50 min to finish and actually got a much better sense of how quantum computers work than before.
Bartosz if you are here (username doesn't seem like it) how long does an article like this take to make? Looking a bit deeper and seeing how there are 10k LOC just in curves.js, and the curves.js seems custom for this, I'd guesstimate 1-3 months of fulltime work.
In any case, thank you for these incredible works of art and science! I had only seen a couple before so I'll have a deep look into the others!
For the last year, I've been self-learning synthetic biology by working to become one of the few people to have ever genetically modified fungi in a diy lab environment[1][2][3]. It occurred to me that genetic engineering is largely a process of hacking biosynthetic pathways; that is, we take heterologous genes from organisms which have evolved novel biochemical pathways and we put them into other organisms that are really good at biosynthesizing those compounds at-scale (like Saccharomyces cerevisiae aka yeast).
One thing I've observed is there seems to be no universal well-annotated structured database for biosynthetic pathways. Updates and additions to known pathways are published unstructured in papers, often in graphical form, presenting even more challenging for structuring the data.
Were this to exist, it would be possible to build an app that let you easily design DNA plasmids for testing all kinds of incredible biosynthesis experiments. For instance, it would be able to select an organism [E. coli], enter your starting substrate [glucose], select a desired metabolite [psilocybin] and out would come a DNA sequence for a plasmid that contains are the necessary parts, promoters, genes and terminators for transforming E. coli to produce psilocybin.
In my opinion, such a tool could profoundly impact science, industry and human well-being.
I've updated it to 600,000 iterations and so far don't see any noticeable impact on performance, both on desktop (using the Firefox extension) and on mobile (iOS).